As of now they're only like combo points, unlike WoW though, in WoW if you use a skill that give you a combo point, as long as the skill hits the target you'll get the combo point. But for rune to apply, even if you hit the target with the skill, there's a chance that it won't apply.
I'm not sure if the debuff will do anything later on, it's possible. ohhh think I get a very cool skill at lvl 19
, too bad I can't lvl until after my Tuesday exam /cry
Not sure if you guys saw the new class videos? Remember the one where the assasin had the enemy stunned in air in a lightening prison thing then strike down at it? I saw a lvl 19 assasin using it >.> WTB T_T