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There's no dynamic binding. One skill per skill bar slot and that's it.
One way you can mitigate the waste of slots is to use a macro to fire all the skills in the combo one after another. However macro system is very primitive, so if the target is out of range after the first skill in the combo the second will not fire, unlike when under manual control you can close-in the distance to fire the second skill, within the short seconds of the combo duration of course. This also won't help branching combos.
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